Before we describe the current books, let us first briefly compare them to the previous book in retrospective. First of all, there were some very promising directions a decade ago that unfortunately did not meet the expectations. Molecular biology and genetics, particularly in regards to expression of stress proteins and other pathways related to the cell injury, have not introduced any serious breakthroughs except for the use of ROCK inhibitors for cryopreservation of human embryonic and induced pluripotent stem cells. The latter really was a revolutionary discovery, which however, was not made by cryobiologists; it was just “picked up” by them from the Watanabe’s seminal work [Watanabe et.
