Basidiomycetes constitute a natural source of biologically active metabolites. Many basidiomycetes have been classified by the National Cancer Institute of the United States as antitumor agents exhibiting an immunomodulatory The therapeutic activity is mainly related to polysaccharides or protein-bound polysaccharides, such as glucans, heterogalactans, and glucanproteins, which are present either in the mycelium or in the fruit –6 Among these polysaccharides are b-D-glucans, which are of particular interest because of their pharmacological properties. Most of the b-D-glucans exhibiting a biological activity have been extracted from Grifola frondosa, Ganoderma lucidum, Trametes versicolor, Schizophyllum commune, Lentinula edodes, and Flammulina velutipes
