This research showed how animal models can predict patient response not just to a particular medicine, but to different combinations of therapy – a critical factor in cancer treatment. for example, animal studies with combinations of tamoxifen and aromatase inhibitors did not show any improvement over established treatments. Professor brodie described how aromatase inhibitor therapy alone had been shown to be the most effective16. Her preliminary research excited doctors who ran the first clinical trial. It was a success and aromatase inhibitors were approved for use in patients with oestrogen- fuelled breast cancer. Later studies with patients showed that sequential treatment.
