After a limited physical examination, palpable FNAB may be performed as clinically indicated. The operator should wear examination gloves as described in standard precautions. 18 The skin should be cleansed with an alcohol swab prior to puncture for superficial FNAB. For percutaneous biopsy of deep lesions, sterile or aseptic technique is used. Local anesthesia may be used for palpable lesions at the preference of the operator and the patient, but is usually used for percutaneous radiologically guided needle biopsies. Sedation is rarely needed for adult superficial FNAB, but may be used for pediatric patients, or deep-seated.