BASP1 (also known as CAP-23 and NAP-22) is a brain abundant myri-stoylated protein localized at the inner surface of the presynaptic plasma membrane. Emerging evidence suggests that BASP1 is critically involved in various cellular processes, in particular, in the accumulation of phosphati-dylinositol-4,5-diphosphate (PIP2) in lipid raft microdomains.