A decade ago, a disintegrin and metalloproteinase 10 (ADAM10) was iden-tified as ana-secretase and as a key proteinase in the processing of the amy-loid precursor protein. Accordingly, the important role that it plays in Alzheimer’s disease was manifested. Animal models with an overexpression of ADAM10 revealed a beneficial profile of the metalloproteinase with respect to learning and memory, plaque load and synaptogenesis.