The abuse of amphetamines is of national concern from a public health perspective. Review of this subject is timely and important, because the problem of amphetamine-like drugs has recently been amplified by the introduction of designer drugs in the illicit market. There has been an increasing number of attempts by chemists in clandestine laboratories to synthesize structurally altered congeners that might intensify the moodaltering property of this class of compounds. While attention over the last few decades has been centered on research related to amphetamine, methamphetamine, and clinically prescribed amphetamine derivatives including fenfluramine, recent attention has focused on a variety of amphetamine-related designer drugs
