Despite my many years of research and teaching in platelet physiology and pharmacology at the University of Minnesota, I am often confronted with conflicting opinions as to the relevance of nonnucleated platelets in human health and disease. It is fascinating to think that how cells with no apparent nucleus, have such a towering impact on concepts, dealing with often overlapping physiological (. hemostasis, wound healing, etc.) and pathophysiological (. thrombosis, stroke, atherosclerosis, wound healing, diabetes, inflammation and cancer) components. Although the idea of compiling new frontiers of platelet research in the form of a book was quite simple at the beginning, the project turned out to be a.
