More than 50 percent of women in low-resource settings deliver without skilled birth attendants and hours away from facilities where these medicines and emergency obstetric care should be available. Managing high blood pressure and related seizures and preventing bleeding for births that are not attended by skilled providers remain major challenges for improving maternal survival. Additional studies are needed to understand the gaps and challenges with regard to policy, regulatory, manufacturing, supply chain management, information systems, financing and demand. Once better understood, the global health organizations and countries around the world will have the information needed to most effectively.