Expression of the tissue inhibitor ofmetalloproteinases-1(Timp-1) gene can be induced by either phorbol myristate acetate (PMA) or transforming growth factorb1 (TGF-b1), although the signalling pathways involved are not clearly defined. Canonically, histone deacetylase inhibitors (HDACi) such as trichostatin A (TSA) or sodium butyrate (NaB) increase total cellular histone acetylation and activate expression of susceptible genes. Remarkably, PMA and TGF-b1 stimulation ofTimp-1show a differential response to TSA or NaB. .
