Genetic and proteomic approaches have led to the identification of 32 pro-teins, collectively called peroxins, which are required for the biogenesis of peroxisomes. Some are responsible for the division and inheritance of per-oxisomes; however, most peroxins have been implicated in the topogenesis of peroxisomal proteins. Peroxisomal membrane and matrix proteins are synthesized on free ribosomes in the cytosol and are imported post-trans-lationally into pre-existing organelles (Lazarow PB & Fujiki Y (1985) Annu Rev Cell Biol1, 489–530 [1])
