This is a further development of my last book Brain, Mind, and the Signifying Body(Thibault 2004a). That book was a first step in an overall attempt to rethink meaning-making activity from the perspective of the body-brain system – the signifying body – embedded in its ecosocial semiotic environment. As I pointed out in the epilogue to that project, the key themes included activity, agency, body-brain system, contextualization, cross-coupling, differentiation, dynamic open systems, ecosocial environment, embodiment, individuation, meaning-making, meta- functions, multimodality, process, scalar hierarchy, self-organization, specification hierarchy, system, timescales, topological, trajectory, typological, and value