Eight adenosine analogs, 3-deaza-adenosine (DZA), 3-deaza-(±)aristeromycin (DZAri), 2¢,3¢-dideoxy-adenosine (ddAdo), 2¢,3¢-dideoxy-3-deaza-adenosine (ddDZA), 2¢,3¢-dideoxy-3-deaza-(±)aristeromycin (ddDZAri), 3-deaza-5¢-(±)noraristeromycin (DZNAri), 3-deaza-neplanocin A (DZNep), and neplanocin A (NepA), were tested as inhibi-tors of human placentaS-adenosylhomocysteine (AdoHcy) hydrolase. The order of potency for the inhibition of human placental AdoHcy hydrolase was: DZNep NepA DZAri DZNAri DZA ddAdo ddDZA ddDZAri
