We have reportedpreviously thatmultiple copies ofMRG19 suppressGALgenes inawild-typebut not inagal80strainof Saccharomyces cerevisiae. In this report we show that dis-ruption ofMRG19leads to a decrease in GALinduction whenS. cerevisiaeis inducedwith but not with galactose. Disruption ofMRG19in agal3background (this strainshows long-termadaptationphenotype)furtherdelays theGALinduction, supporting the notion that its function is important only under low inducing signals.