Objectives: To evaluate quantitative results of serotonin plasma concentrations in generalized tonic-clonic seizure patients with combined depression. Subjects and methods: A cross-sectional study of serotonin serum concentrations at T0 (start of study) and T8 (after 8 weeks of treatment) is the result of random selection of 88 out of 102 generalized tonic-clonic seizure patients with combined depression at Haiphong Psychiatric Hospital from April, 2013 to October, 2015. | Journal of military pharmaco-medicine n08-2017 QUANTITATIVE RESULT OF SEROTONIN PLASMA CONCENTRATIONS IN GENERALIZED TONIC-CLONIC SEIZURE PATIENTS WITH COMBINED DEPRESSIVE DISORDER Pham Van Thang*; Bui Quang Huy**; Ngo Ngoc Tan** SUMMARY Objectives: To evaluate quantitative results of serotonin plasma concentrations in generalized tonic-clonic seizure patients with combined depression. Subjects and methods: A cross-sectional study of serotonin serum concentrations at T0 (start of study) and T8 (after 8 weeks of treatment) is the result of random selection of 88 out of 102 generalized tonic-clonic seizure patients with combined depression at Haiphong Psychiatric Hospital from April, 2013 to October, 2015. Results: Serotonin in the average plasma concentration at time T0 was ± ng/mL, at the time T8 ± ng/mL. The relationship between serotonin serum and some generalized tonic-clonic seizures with combined depression such as: the mild depression was ( ± ng/mL) higher than the severe depression ( ± ng/mL). Conclusion: There is not difference in plasma serotonin levels with clinical manifestations of organic depressive disorder, duration of depression, duration of epilepsy. * Keywords: Generalized tonic-clonic seizures; Depressive disorder; Serotonin concentration. INTRODUCTION People with epilepsy often have accompanied depressive disorders. Serotonin levels in plasma are thought to be associated with depressive disorder, and in depressed patients, these levels are markedly lower than those of normal people, sometimes as high as 30%. In Vietnam, quantitative serotonin levels in epilepsy patients with depression have not yet been studied. With such importance, the objectives of this study is: Evaluate quantitative results of serotonin plasma concentrations in generalized tonic-clonic seizure patients with combined depressive disorder. SUBJECTS AND METHODS 1. Subjects. 88 inpatients with generalized tonic-clonic seizures .
