This study aimed to determine the effects of an herbal formula named TD0014 on the electrostimulationinduced erection in a rat model. Eighteen sixteen-week-old male Wistar rats were used. The intracavernous pressure and the arterial blood pressure were simultaneously monitored during cavernous nerve electrical stimulation before and after the administration of TD0014 ( g/kg). | JOURNAL OF MEDICAL RESEARCH EFFECT OF TD0014 ON INTRACAVERNOUS PRESSURE ELICITED WITH ELECTRICAL STIMULATION OF THE CAVERNOUS NERVE IN MALE RATS Mai Phuong Thanh1, Pham Thi Van Anh1, Nguyen Trong Thong1, Nguyen Thi Huong Lien 2 1 Department of Farmacology, Hanoi Medical University, 2Sunstar Joint Stock Company This study aimed to determine the effects of an herbal formula named TD0014 on the electrostimulationinduced erection in a rat model. Eighteen sixteen-week-old male Wistar rats were used. The intracavernous pressure and the arterial blood pressure were simultaneously monitored during cavernous nerve electrical stimulation before and after the administration of TD0014 ( g/kg). Statistical analysis was performed on measurements of maximal intracavernous pressure (MIP), mean arterial blood pressure (MAP) and the MIP/MAP. The administration of TD0014 resulted in a significant increase in the baseline level of intracavernosal pressure (ICP) before stimulation in comparison to the control group (P ) MIP/MAP increased significantly compared with distilled water group and TD0014 group (p ). Thus, in the current study, TD0014 given once before nerve stimulation markedly increased baseline ICP, slightly increased both the MIP and the response time to the stimulus. These results suggested that TD0014 may be beneficial for patients with erectile dysfunction, and can improving the patient's sexual life. JMR 111 E2 (2) - .
