From our prior studies concerning eugenol’s biologic activity we observed the very good in vitro antifungal efficiency of this natural compound. Those positive results generated the need to supplement the available information with a comparative in vivo animal model. | Turkish Journal of Biology Research Article Turk J Biol (2015) 39: 455-460 © TÜBİTAK doi: Eugenol biologic activity in immunosuppressed rat females with Candida albicans genital infection: histocytological changes 1, 1 1 Romeo Teodor CRISTINA *, Diana OBIȘTIOIU , Eugenia DUMITRESCU , 2 3 4 5 Ileana NICHITA , Florin MUSELIN , Diana BREZOVAN , Mihai Sorin CERNEA 1 Departments of Pharmacology and Pharmacy, Faculty of Veterinary Medicine, Banat’s University of Agriculture and Veterinary Medicine “King Michael I of Romania”, Timișoara, Romania 2 Department of Mycology, Faculty of Veterinary Medicine, Banat’s University of Agriculture and Veterinary Medicine “King Michael I of Romania”, Timișoara, Romania 3 Department of Botany, Faculty of Veterinary Medicine, Banat’s University of Agriculture and Veterinary Medicine “King Michael I of Romania”, Timișoara, Romania 4 Department of Histology and Molecular Biology, Faculty of Veterinary Medicine, Banat’s University of Agriculture and Veterinary Medicine “King Michael I of Romania”, Timișoara, Romania 5 Departments of Pharmacology and Pharmacy, Faculty of Veterinary Medicine, University of Agriculture and Veterinary Medicine, Cluj Napoca, Romania Received: Accepted/Published Online: Printed: Abstract: From our prior studies concerning eugenol’s biologic activity we observed the very good in vitro antifungal efficiency of this natural compound. Those positive results generated the need to supplement the available information with a comparative in vivo animal model. In this context, our current study was proposed to ascertain and compare the effects of eugenol with nystatin with a placebo control group (saline solution) by evaluating the cytohistological alterations in immunosuppressed Wistar female rats genitally infected with Candida albicans. The observed histological alterations were most apparent in the placebo group. .
