Nghiên cứu này nhằm đánh giá tác dụng hạ đường huyết của dịch chiết cồn 70 độ C của lá dây thìa canh, lá cỏ ngọt, vỏ quế, râu bắp và lá húng quế trên chuột ĐTĐ gây ra bởi streptozocin. Kết quả chứng minh rằng cao lá dây thâm canh và lá cỏ ngọt có khả năng hạ đường huyết đáng kể ở liều 5 mg so với nhóm chuột đối chứng (P | Nghiên cứu tác dụng hạ đường huyết và chống oxy hóa của một số cao chiết thực vật TAP CHI SINH HOC 2019, 41(2): 119–128 DOI: STUDY OF ANTIHYPERGLYCAEMIC ACTIVITY IN STREPTOZOTOCIN INDUCED DIABETIC MICE AND ANTIOXIDANT ACTIVITIES OF MEDICINAL PLANT EXTRACTS Nguyen Thi Xuan Thu1,*, Dang Duc Long2, Thanh Thi Thu Thuy3 1 University of Science and Technology, The University of Danang, Vietnam 2 VN-UK Institute for Research and Executive Education, The University of Danang, Vietnam 3 Institute of Chemistry, VAST, Vietnam Received 24 April 2019, accepted 25 June 2019 ABSTRACT Some extracts of medicinal plants have been proven to be beneficial in treating a number of diseases for centuries such as treating diabetes, antioxidant, anti-inflammatory, antibacterial, etc. This study aimed to evaluate the effect of extracts from several herbal plants, such as Gymnema sylvestre, Stevia rebaudiana, Cinnamomum cassia, Zea may, Ocimum basilicumon on blood glucose level in streptozotocin (STZ) induced diabetic mice and to offer scientific proofs for the identified antihyperglycemic effect by investigating on mechanisms of the most effective extract. The results proved that diabetic mice treated with 70% ethanol extracts of Gymnema sylvestre leaves and Stevia rebaudiana leaves showed significant reduction of the blood glucose levels at a dose of 500 mg/kg body weight when compared to control (P < ). Antihyperglycemic activity of Gymnema sylvestre () and Stevia rebaudiana extracts () was significantly higher than those of other extracts. The inhibition of α-amylase and α-glucosidase activity of Gymnema sylvestreand, Stevia rebaudiana extracts were carried out in vitro. The results demonstrated that these Gymnema sylvestre and Stevia rebaudiana extracts were able to strongly inhibit the activity of α-glucosidase and α-amylase, with the IC50 values lower than the .
