The worldwide spread of carbapenem-resistant Enterobacteriaceae (CRE) has become a major challenge in healthcare settings. This study aimed to screen the susceptibility to imipenem and meropenem, among 49 Klebsiella and 7 Proteus vulgaris clinical isolates from Egypt. The combinations of carbapenems with ciprofloxacin, rifampicin, amikacin and colistin were tested against CRE. Attempts to cure plasmids mediating carbapenem resistance using menthol, as a natural curing agent, as well as to test its efficacy when combined with other antibiotics against CRE, were done. A comparison was done between phenotypic methods and polymerase chain reaction for the differentiation of carbapenemases. | Prevalence of carbapenem resistant klebsiella and proteus clinical isolates: A real threat to the Egyptian health care system
