Aiming at the characteristics of nonlinear, multi-parameter, strong coupling and difficulty in direct online measurement of key biological parameters of marine low-temperature protease fermentation process, a softsensing modeling method based on artificial bee colony (ABC) and multiple least squares support vector machine (MLSSVM) inversion for marine protease fermentation process is proposed. | Soft - sensing modeling based on ABC - MLSSVM inversion for marine low - temperature alkaline protease MP fermentation process