An effective and expeditious method of the synthesis of a highly functionalized piperidines, catalyzed by nontoxic, recyclable and environment friendly sodium lauryl sulfate (SLS), via one-pot multi-component condensation of aldehydes, amines and β-ketoesters in water at room temperature, has been developed. | One-pot multi-component green synthesis of highly substituted piperidines Current Chemistry Letters 6 2017 135 142 Contents lists available at GrowingScience Current Chemistry Letters homepage One-pot multi-component green synthesis of highly substituted piperidines Ravi Bansal Pradeep K. Soni Jyoti Sharma Santosh K. Bhardwaj and Anand K. Halve School of Studies in Chemistry Jiwaji University Gwalior . INDIA- 474011 CHRONICLE ABSTRACT Article history An effective and expeditious method of the synthesis of a highly functionalized piperidines Received January 2 2017 catalyzed by nontoxic recyclable and environment friendly sodium lauryl sulfate SLS via Received in revised form one-pot multi-component condensation of aldehydes amines and β-ketoesters in water at room March 1 2017 temperature has been developed. This new protocol has advantages such as moderate to high Accepted March 6 2017 yields of products obtained after simple post reaction workup. Structure of the synthesized Available online compounds 4a 4j have been elucidated based on the 1H NMR 13C NMR FT-IR spectroscopy March 6 2017 and elemental analysis. Keywords Heterocycles Piperidines Multi-component synthesis Catalyst Sodiumlaurylsulfate SLS 2017 Growing Science Ltd. All rights reserved. 1. Introduction Heterocyclic compounds containing nitrogen atom are wide spread in nature and have significant practical importance because of their applications in medicine and 2 They are also used as functional materials. The development of new and efficient methods for the synthesis of N-heterocycles is one of the greater interests of modern synthetic organic Synthesis of complex heterocyclic molecules can be easily achieved starting from readily available starting materials in a single step multi-component reactions MCRs .6 In most of the cases these reactions are advantageous over the linear step-wise syntheses because of the operational simplicity shorter .
