U nguyên bào gan là loại u gan ác tính thường gặp nhất ở trẻ em. Nghiên cứu này mô tả đặc điểm lâm sàng và cận lâm sàng u nguyên bào gan ở trẻ em được phẫu thuật tại khoa Ngoại Bệnh viện Nhi Trung ương từ 1/2016 đến 8/2019. | Journal of Pediatric Research and Practice Vol. 4 No. 4 2020 8-16 Research Paper Clinical and Investigation of Pediatric Patients with Hepatoblastoma at Vietnam National Children s Hospital Pham Duy Hien1 Tran Duc Tam1 Phan Hong Long2 1 Vietnam National Children s Hospital 18 879 La Thanh Dong Da Hanoi Vietnam 2 Hanoi Medical University 01 Ton That Tung Dong Da Hanoi Vietnam Received 16 July 2020 Revised 14 August 2020 Accepted 17 August 2020 Abstract Background Purpose Hepatoblastoma is the most common malignant liver tumor in children. Study on clinical and investigations of pediatric patients with hepatoblastoma at Vietnam National Children s Hospital from Jan 2016 to Aug 2019. Methods A total 30 patients with Hepatoblastoma were operated at Vietnam National Children s Hospital from January 2016 to August 2019. The study design is retrospective. Resullts Study subject s mean of age was 36 8 months range 4 - 149 months the common group of age was under 5 years old 76 7 male s more than female 56 7 and 43 3 . The most common clinical symptoms were hepatomegaly 50 a palpable abdominal mass 30 abdominal pain 13 3 secondary anemia 13 3 weight loss 6 7 jaundice 3 3 . About laboratory test 83 3 patients with anemia 36 7 patients with thrombocytosis 90 patients with hight GOT levels 53 3 patients with hight GPT levels 96 7 patients with hight serum AFP levels and the average value of AFP was 217160 7 ng ml range 575 - 1686328 6 ng ml . Mean size of the tumor on computerized tomography was 5 48cm range 2 - 15cm 60 size of tumor 5cm 96 7 had only one tumor 70 primary tumor located to the right lobe of the liver 76 7 were staged PRETEXT II the most common hepatoblastoma histopathological subtypes was as follows epithelial 80 . Conclusions Clinical symptoms of hepatoblastoma are usually nonspecific. A routine check - up strategy for early detection of hepatoblastoma and the role of investigations in diagnosis is very important. Keywords Hepatoblastoma Children. ____ .
