The objectives of the thesis: Determine the chemical composition of three soft coral species S. nanolobata, S. conferta, S. leptoclados collected in the central sea of Vietnam; đetecting active substances with cytotoxic activity in soft corals studied, orienting their application for biomedical and pharmacological studies. | MINISTRY OF EDUCATION VIETNAM ACADEMY OF AND TRAINING SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY OF SCIENCE AND TECHNOLOGY - Ninh Thi Ngoc STUDY ON CYTOTOXIC ACTIVITY OF SOME CANCER CELL LINES OF ISOLATED COMPOUNDS FROM THREE SOFT CORALS SINULARIA NANOLOBATA SINULARIA LEPTOCLADOS SINULARIA CONFERTA COLLECTED FROM THE SEA AREA OF CENTRAL VIETNAM Major Biochemistry Code SUMMARY OF BIOLOGY DOTORAL THESIS Ha Noi - 2021 This thesis was completed at Graduate university of Science and Technology - Vietnam Academy of Science and Technology - Institute of Biotechnology - Institute of Marine Biochemistry Advisor 1 PhD. Nguyen Hoai Nam Advisor 2 PhD. Tran My Linh Reviewer 1 Assoc. Prof. PhD. Nguyen Dinh Thang Reviewer 2 Assoc. Prof. PhD. Tran Thu Huong Reviewer 3 PhD. Bui Thi Thuy Luyen This thesis will be defended at Graduate University of Science and Technology - Vietnam Academy of Science and Technology at hour date month 2021. The thesis can be found in - The Library of Graduate University of Science and Technology Vietnam Academy of Science and Technology. - National Library of Vietnam. - Institute of Biotechnology 1 INTRODUCTION 1. The urgency of the thesis In recent years many countries have exploited bioactive substances from marine organisms to serve researches to find drugs to treat dangerous diseases such as cancer hepatitis and diseases infections and viruses. Up to this point a number of pharmaceuticals derived from marine organisms have reached the users hands such as Cytarabine Vidarabine Eribulin Trabectedin . To achieve this achievement research institutes around the world has screened the biological activity of millions of compounds from marine species and invested financial resources and time in pre-clinical and clinical research phases for potential compounds. With the advantage of owning a long coastline of over km along with many islands and bays Vietnam has great potential for exploiting a diverse marine resources rich in both species
