The prognosis of pancreatic cancer (PC) has been improved by new chemotherapy regimens (combination of 5-fuorouracil, oxaliplatin, irinotecan, and leucovorin (FOLFIRINOX) or gemcitabine plus nab-paclitaxel (GnP)). Unfortunately, chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse event of these two regimens. The efficacy of pregabalin for CIPN has been reported in previous studies. | Sugimoto et al. BMC Cancer 2021 21 1319 https s12885-021-09069-9 RESEARCH Open Access Mirogabalin vs pregabalin for chemotherapy-induced peripheral neuropathy in pancreatic cancer patients Mitsuru Sugimoto1 Tadayuki Takagi1 Rei Suzuki1 Naoki Konno1 Hiroyuki Asama1 Yuki Sato1 Hiroki Irie1 Yoshinori Okubo1 2 Jun Nakamura1 2 Mika Takasumi1 Minami Hashimoto1 2 Tsunetaka Kato1 2 Ryoichiro Kobashi1 Takuto Hikichi2 and Hiromasa Ohira1 Abstract Background The prognosis of pancreatic cancer PC has been improved by new chemotherapy regimens combi- nation of 5-fluorouracil oxaliplatin irinotecan and leucovorin FOLFIRINOX or gemcitabine plus nab-paclitaxel GnP . Unfortunately chemotherapy-induced peripheral neuropathy CIPN is a common adverse event of these two regi- mens. The efficacy of pregabalin for CIPN has been reported in previous studies. However the efficacy of mirogabalin for CIPN remains unknown. Thus in this study we aimed to clarify which drug mirogabalin or pregabalin was more valuable for improving CIPN. Methods A total of 163 PC patients who underwent FOLFIRINOX or GnP between May 2014 and January 2021 were enrolled. Among them 34 patients were diagnosed with CIPN. Thirteen patients were treated with mirogabalin miro- gabalin group and twenty-one patients were treated with pregabalin pregabalin group . Treatment efficacy was compared between the two groups. Results In both the mirogabalin group and the pregabalin group the grade of patients with CIPN at 2 4 and 6 weeks after the initiation of treatment showed significant improvement compared to the pretreatment grade. Nota- bly the rate of CIPN improvement was higher in the mirogabalin group than in the pregabalin group 2 weeks 11 13 vs 7 21 P value 4 weeks 6 weeks 12 13 vs 7 21 P value . Conclusions Although both mirogabalin and pregabalin were effective at improving CIPN mirogabalin might be a suitable first choice for CIPN in PC patients. Trial registration .
