As segmentectomy had become commonly used for Non-Small Cell Lung Cancer (NSCLC) treatment, which had the advantages of radical operation, however, it remains controversial owing to procedural complexity and risk of increased complications compared with wedge resection. | Zhou et al. BMC Cancer 2022 22 71 https s12885-021-09129-0 RESEARCH Open Access Comparison of surgical outcomes and prognosis between wedge resection and simple Segmentectomy for GGO diameter between 2 cm and 3 cm in non-small cell lung cancer a multicenter and propensity score matching analysis Yaodong Zhou1 Tao Yu1 Yixin Zhang2 Liqiang Qian3 and Qing Xia4 Abstract Background As segmentectomy had become commonly used for Non-Small Cell Lung Cancer NSCLC treatment which had the advantages of radical operation however it remains controversial owing to procedural complexity and risk of increased complications compared with wedge resection. We evaluated operative and postoperative outcomes of simple segmentectomy compared to wedge resection in ground-glass opacity GGO diameter between 2 cm and 3 cm NSCLC. Methods We retrospectively reviewed 1600 clinical GGO diameter between 2 cm and 3 cm NSCLC patients who received simple segmentectomy and wedge resection between Jan 2011 and Jan 2015. Participants were matched 1 1 on their propensity score for two groups. Clinic-pathologic operative and postoperative results of two groups were compared. Results After using propensity score methods to create a matched cohort of participants with simple segmentec- tomy group similar to that wedge resection there were no significant differences detected in tumor size margin dis- tance histology age sex preoperative comorbidities and preoperative pulmonary function. Overall complications in simple segmentectomy group were more than wedge resection group 21 vs 3 p . Median operative time vs. min p and prolonged air leakage 12 vs. 3 p was significantly longer in the simple segmentectomy group. There was no difference in recurrence free survival RFS and overall survival OS of 5-years between simple segmentectomy group and wedge resection group. Postoperative pulmonary function in simple segmentectomy group recovered more slowly than wedge .
