Nghiên cứu và phát triển cảm biến điện hóa không gắn enzyme dựa trên điện cực ZnO/graphen xốp nhằm xác định xanthin

Trong nghiên cứu này, một cảm biến điện hóa không gắn enzyme sử dụng điện cực graphen xốp được biến tính với hạt nano ZnO (cảm biến ZnO/fPGE) đã được phát triển để xác định hàm lượng xanthin (XA). Cảm biến ZnO/fPGE được chế tạo bằng phương pháp thủy nhiệt và kỹ thuật ghi laze hồng ngoại CO2 trên màng polyimide. | Vietnam Journal of Food Control A Scientific Journal of National Institute for Food Control Journal homepage https Research Article Research and development of non-enzymatic electrochemical sensors utilizing porous ZnO graphene electrodes to determine xanthine Ta Ngoc Bach1 Nguyen Xuan Viet2 Nguyen Van Anh2 Pham Quang Trung2 Nguyen Thi Minh Thu2 Phung Thi Thu3 Vu Hong Ky1 Do Hung Manh1 Vu Dinh Lam4 Nguyen Huy Dan1 Trinh Xuan Anh5 Ngo Thi Hong Le1 4 1 Institute of Materials Science Vietnam Academy of Science and Technology Hanoi Vietnam 2 Faculty of Chemistry University of Science Vietnam National University Hanoi Vietnam 3 University of Science and Technology of Hanoi Vietnam Academy of Science and Technology Hanoi Vietnam 4 Graduate University of Science and Technology Vietnam Academy of Science and Technology Hanoi Vietnam 5 Hanoi University of Science and Technology Hanoi Vietnam Received 15 Jan 2024 Revised 21 Jan 2024 Accepted 02 Feb 2024 Abstract In this study we developed a non-enzymatic electrochemical sensor using a porous graphene electrode modified with ZnO nanoparticles ZnO fPGE sensor to determine xanthine XA content. The ZnO fPGE sensor is fabricated using a hydrothermal method and CO2 infrared laser writing technique on a polyimide film. The morphology structure and properties of the ZnO fPGE were meticulously characterized using Raman spectroscopy field-emission scanning electron microscopy FE-SEM and Von-Ampe spectroscopy methods. The ZnO fPGE sensor exhibited a broad linear response range from 1 µM to 100 µM a low limit of detection LOD of µM high sensitivity at .cm and demonstrated effective resistance to common interferences such as uric acid ascorbic acid dopamine glucose and xanthine. Notably the ZnO fPGE sensor has created a conducive electrical environment for the advancement of high-performance electrochemical biosensors specifically for the precise determination of xanthine levels in meat and fish .