Table 116-3 Valid and Invalid Contraindications to Vaccination Vaccine Valid Contraindicationa Invalid Contraindication All vaccines in general Serious allergic Mild acute illness with reactions (., anaphylaxis) or without fever to a previous vaccine dose or a vaccine component Precaution: Moderate Mild to moderate local or severe concurrent illness reactions; with or without fever moderate low-grade fever after or a previous dose Lack of previous physical examination in a well-appearing person Current antimicrobial therapy (except certain live bacterial vaccines) Convalescent phase of illness Premature birth (except hepatitis B in some circumstances) Recent exposure to infectious diseases History of penicillin allergy, allergies; allergies; other nonvaccine with relatives receiving desensitization treatment DTaPb Severe allergic Temperature fussiness | Chapter 116. Immunization Principles and Vaccine Use Part 9 Table 116-3 Valid and Invalid Contraindications to Vaccination Vaccine Valid Contraindication Invalid Contraindication All vaccines in general Serious allergic reactions . anaphylaxis to a previous vaccine dose or a vaccine component Mild acute illness with or without fever Precaution Moderate Mild to moderate local or severe concurrent illness with or without fever reactions low-grade or moderate fever after a previous dose Lack of previous physical examination in a well-appearing person Current antimicrobial therapy except certain live bacterial vaccines Convalescent phase of illness Premature birth except hepatitis B in some circumstances Recent exposure to infectious diseases DTaPè History of penicillin allergy other nonvaccine allergies relatives with allergies receiving desensitization treatment Severe allergic reaction to a previous dose or a vaccine component Temperature of C fussiness mild drowsiness after a prior dose of DTP or DTaP Encephalopathy . coma decreased level of consciousness prolonged seizures within 7 days of a previous dose of DTP or DTaP Family history of seizures sudden infant death syndrome or adverse event after DTP or DTaP Progressive neurologic disorder including infantile spasms Stable neurologic conditions . cerebral palsy .