Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: A road map of yeast interactions. | J. Biol. Journal of Biology BioMed Central Research news A road map of yeast interactions Jonathan B Weitzman Published 1 June 2005 Journal of Biology 2005 4 4 The electronic version of this article is the complete one and can be found online at http content 4 2 4 2005 BioMed Central Ltd Analysis of a yeast network that integrates five interaction datasets reveals the presence of large topological structures reflecting biological themes. Open any atlas and you will find a variety of maps for each country or territory. These will include information about different features such as geology climate population and so on. Integrating information from the different maps allows the reader to appreciate the landscape they are exploring. The same is true for cellular maps that chart genetic protein or functional interactions within the cell. Now in Journal of Biology 1 Frederick Fritz Roth from Harvard Medical School and colleagues from Toronto and Montreal describe key topological features of an enormous map of macromolecular interactions in yeast see The bottom line box for a summary of the work . Integrating interaction maps Cellular processes can be explored by investigating interactions between biological components. The complex system of the cell is a network of interconnections - proteins interact with other proteins or with DNA and genes can interact functionally with one another. Large-scale projects have attempted to define the entire list of genetic components the genome their expression patterns the transcriptome their protein products the pro-teome and the interactions between them the interactome . A key challenge is to integrate these different maps so as to develop a conceptual model for dynamic cellular behavior. Roth and colleagues have created an integrated network map that incorporates five different types of biological interaction data for the yeast The bottom line An integrated network has been constructed by combining five different types .
