Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Astrocytes derived from glial-restricted precursors promote spinal cord repair. | J. Biol. Journal of Biology BioMed Central Research article Open Access Astrocytes derived from glial-restricted precursors promote spinal cord repair Jeannette E Davies Carol Huang Christoph Proschel Mark Noble Margot Mayer-Proschel and Stephen JA Davies Addresses Department of Neurosurgery Baylor College of Medicine 1709 Dryden Street Suite 750 Houston Texas 77030 USA. Department of Neuroscience Baylor College of Medicine 1 Baylor Plaza Houston Texas 77030 USA. Department of Biomedical Genetics University of Rochester Medical Center 601 Elmwood Avenue Rochester New York 14642 USA. Correspondence Stephen JA Davies. Email sdavies@ Received 5 November 2005 Revised 21 March 2006 Accepted 22 March 2006 Published 27 April 2006 Journal of Biology 2006 5 7 The electronic version of this article is the complete one and can be found online at http content 5 3 7 2006 Davies et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Transplantation of embryonic stem or neural progenitor cells is an attractive strategy for repair of the injured central nervous system. Transplantation of these cells alone to acute spinal cord injuries has not however resulted in robust axon regeneration beyond the sites of injury. This may be due to progenitors differentiating to cell types that support axon growth poorly and or their inability to modify the inhibitory environment of adult central nervous system CNS injuries. We reasoned therefore that pre-differentiation of embryonic neural precursors to astrocytes which are thought to support axon growth in the injured immature CNS would be more beneficial for CNS repair. Results Transplantation of astrocytes derived from embryonic glial-restricted precursors GRPs .
