Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Multilevel regulation of growth rate in yeast revealed using systems biology. | Journal of Biology BioMed Central Minireview Multilevel regulation of growth rate in yeast revealed using systems biology Arvind Ramanathan and Stuart L Schreiber Address The Broad Institute of Harvard MIT Chemical Biology Program 7 Cambridge Center Cambridge MA 02142 USA. Correspondence Stuart L Schreiber. Email stuart_schreiber@ Published 30 April 2007 Journal of Biology 2007 6 3 The electronic version of this article is the complete one and can be found online at http content 6 1 3 2007 BioMed Central Ltd Abstract The effect of changing growth rates on the transcriptome proteome and metabolome has been systematically studied. Measurements made under varying nutrient conditions corresponding to biochemical pathways that correlate primarily with growth rate reveal a central role for mitochondrial metabolism and the TOR target of rapamycin signaling pathway. Growth is a fundamental property of living things and understanding what regulates cell growth has important clinical implications in conditions such as developmental disorders and cancer. Cell growth is in general regulated by a linkage between growth rate cell size and cell division. In some types of growth however such as the increase in size of fully differentiated muscle fibers or the outgrowth of neurites from a developing neuron regulated growth occurs in the absence of cell division. The overall coordination of a complex phenomenon like cell growth in the context of cell cycle cell size nutrients and energy metabolism must involve an interrelated set of molecular mechanisms. The following questions remain unanswered - at steady state during every cell cycle how do cells regulate their energy metabolism and biosynthetic pathways in order to double mass while maintaining the same cell size distribution after cell division In proliferating cells with increasing growth rates in addition to coordinating the length of the cell cycle what biochemical and signaling pathways need to be .
