Tuyển tập các báo cáo nghiên cứu khoa học trên tạp chí khoa học vật lý quốc tế đề tài: Evaluation of In Vitro Antioxidant Activity of 5H-dibenz[b,f]azepine and Its Analogues | Journal of Physical Science Vol. 21 1 79-92 2010 79 Evaluation of In Vitro Antioxidant Activity of 5H-dibenz b f azepine and Its Analogues Vijay Kumar Honnaiah1 Ranga Rao Ambati2 Varakumar Sadineni3 and Nagaraja Naik1 department of Studies in Chemistry University of Mysore Manasagangotri Mysore - 570 006 Karnataka India department of Oils and Fats V. R. S. Y. R. N. College Acharya Nagarjuna University Chirala - 523 157 Andhra Pradesh India department of Biochemistry Sri Venkateswara University Tirupati - 517 502 Andhra Pradesh India Corresponding author drnaik_chem@ Abstract Synthesis of 5H-dibenz b f azepine and its derivatives bearing different functional groups was performed. The compounds thus synthesised were evaluated for their antioxidant activities by following two well established assays inhibitory activity on human low density lipoprotein LDL oxidation and lipid peroxidation activity in an egg liposome model system. Among the compounds a and d significantly inhibited human LDL oxidation and liposome peroxidation whereas compounds b c e and f showed less activity. Butylated hydroxy anisole BHA and ascorbic acid AA were used as reference antioxidant compounds. Comparative studies with the synthesised compounds were also performed. Keywords 5H-dibenz b f azepine LDL oxidation lipid peroxidation antioxidant activity 1. INTRODUCTION Free radicals and active oxygen species have been correlated with cardiovascular and inflammatory diseases and even with a role in cancer and 2 Efforts to counteract the damage caused by these species are gaining acceptance as a basis for novel therapeutic approaches and the field of preventive medicine is experiencing an upsurge of interest in medically useful 4 Recent evidence5 suggests that free radicals which are generated in many bioorganic redox processes may induce oxidative damage in various components of the body . lipids proteins and nucleic acids and may also be involved in processes
