Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: An immunohistochemical study of the gastrointestinal endocrine cells in the ddY mice | J. Vet. Sci. 2004 5 2 87-95 JOURNAL OF Veterinary Science An immunohistochemical study of the gastrointestinal endocrine cells in the ddY mice Sae-kwang Ku Hyeung-sik Lee1 Jae-hyun Lee2 Pharmacology Toxicology Lab. Central Research Laboratories Dong-Wha Pharm. Ind. Co. Anyang 430-017 Korea Department of Herbal Biotechnology Daegu Haany University Daegu 712-715 Korea Department of Histology College of Veterinary Medicine Kyungpook National University Daegu 702-701 Korea The distributions and frequencies of some endocrine cells in the gastrointestinal GI tract of ddY mice were studied with immunohistochemical method using 7 types of antisera against bovine chromogranin BCG serotonin gastrin cholecystokinin CCK -8 somatostatin glucagon and human pancreatic polypeptide HPP . All of 7 types of immunoreactive IR cells were identified. Most of IR cells in the intestinal portion were generally spherical or spindle in shape open typed cell while cells showing round in shape close typed cell were found in the intestinal gland and stomach regions occasionally. Their relative frequencies were varied according to each portion of GI tract. BCG-IR cells were demonstrated throughout whole GI tract except for the cecum and they were most predominant in the fundus and pylorus. Serotonin-IR cells were detected throughout whole GI tract and they were most predominant cell types in this species of mice. Gastrin-IR cells were restricted to the pylorus and CCK-8-IR cells were demonstrated in the pylorus duodenum and jejunum with numerous frequencies in the pylorus. Somatostatin-IR cells were detected throughout whole GI tract except for the cecum and rectum and they showed more numerous frequencies in the stomach regions. In addition glucagon-IR cells were restricted to the fundus duodenum and jejunum with rare frequencies and HPP-IR cells were restricted to the rectum only with rare frequency. In conclusion some strain-dependent unique distributional patterns of gastrointestinal .
