Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Clinical pharmacokinetics of norfloxacin-glycine acetate after intravenous and oral administration in pigs | J. Vet. Sci. 2007 8 4 353-356 JOURNAL OF Veterinary Science Clinical pharmacokinetics of norfloxacin-glycine acetate after intravenous and oral administration in pigs 1 2 3 1 4 5 Zhi-Qiang Chang Byung-Chol Oh Jong-Choon Kim Kyu-Shik Jeong Myung-Heon Lee Hyo-In Yun Mi-Hyun Hwang1 Seung-Chun Park1 College of Veterinary Medicine Kyungpook National University Daegu 702-701 Korea 2Lee Gil Ya Cancer and Diabetes Institute Gachon University of Medicine and Science Incheon 406-840 Korea 3College of Veterinary Medicine Chonnam National University Kwangju 500-757 Korea 4National Veterinary Research and Quarantine Service Anyang 430-824 Korea 5College of Veterinary Medicine Chungnam National University Daejeon 302-305 Korea The pharmacokinetics and dosage regimen of norfloxa-cin-glycine acetate NFLXGA was investigated in pigs after a single intravenous . or oral . administration at a dosage of mg kg body weight. After both . and . administration plasma drug concentrations were best fitted to an open two-compartment model with a rapid distribution phase. After . administration of NFLXGA the distribution ti 2a and elimination half-life ti 2p were h and h respectively. The volume of distribution of NFLXGA at steady state Vdss was l kg. After . administration of NFLXGA the maximal absorption concentration Cmax was qg ml at h Tmax . The mean absorption ti 2ka and elimination half-life ti 2P of NFLXGA were h and h respectively. The mean systemic bioavailability F after . administration was . We suggest that the optimal dosage calculated from the pharmacokinetic parameters is mg kg per day . or mg kg per day . Key wolds norfloxacin pharmacokinetics pig Introduction Fluoroquinolones are a group of synthetic antimicrobial agents that are highly potent and exhibit a broad spectrum of activity against a variety of mycoplasmas and Gram-negative bacteria and some .
