Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: The combination of deoxynivalenol and zearalenone at permitted feed concentrations causes serious physiological effects in young pigs | J. Vet. Sci. 2008 9 1 39-44 JOURNAL OF Veterinary Science The combination of deoxynivalenol and zearalenone at permitted feed concentrations causes serious physiological effects in young pigs 1 t 1 t 2 1 1 1 r .l Feng Chen Yulin Ma Chunyi Xue Jingyun Ma Qingmei Xie Genhu Wang Yingzuo Bi Yongchang Cao College of Animal Science South China Agricultural University Guangzhou 510642 P R China 2State Key Laboratory of Biocontrol College of Life Sciences Sun Yat-sen University Guangzhou 510275 P R China This study was to investigate the effects of the combination of deoxynivalenol DON and zearalenone ZON on pigs. Twenty-four weaning piglets were divided into a control group fed a diet free of mycotoxins and a toxin group fed a diet containing 1 mg kg DON and 250 -g kg ZON. The results showed that supplementation of DON and ZON in diets had extensive effects on pigs. More specifically DON and ZON caused levels of total protein albumin and globulin in sera to decrease p by and respectively and at the same time increased p the serum enzyme activities of Y-glutamyltransferase aspartate aminotransferase and alanine aminotransferase by and respectively. In addition DON and ZON decreased p the level of anti-classical swine fever antibody titers by . Real-time PCR showed that DON and ZON caused the mRNA expression levels of IFN-Y TNF-a IL-2 to decrease p by and respectively. Histopathological studies demonstrated that DON and ZON caused abnormalities in the liver spleen lymph nodes uterus and kidney. The concentrations of DON and ZON used in this study are in line with the published critical values permitted by BML. Our study clearly put the standard and adequacy of safety measures for these toxins into question. The authors suggest that with the increasing availability of cellular and molecular technologies it is time to revisit the safety standards for toxins in feeds so as to make feeds safer providing .
