Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Radioprotective effects of fucoidan on bone marrow cells: improvement of the cell survival and immunoreactivity | J. Vet. Sci. 2008 9 4 359-365 JOURNAL OF Veterinary Science Radioprotective effects of fucoidan on bone marrow cells improvement of the cell survival and immunoreactivity 1 2 1 2 1x71 3 1 3 Yun-Young Byon Mi-Hyoung Kim Eun-Sook Yoo Kyu-Kye Hwang Youngheun Jee Taekyun Shin Hong-Gu Joo1 4 College of Veterinary Medicine 2Department of Pharmacology College of Medicine 3Applied Radiological Science Research Institute 4The Research Institute for Subtropical Agriculture and Biotechnology Cheju National University Jeju 690-756 Korea Fucoidan is a sulfated polysaccharide purified from brown algae including Fucus vesiculosus and has a variety of biological effects including mobilization of hematopoietic progenitor cells. Recently we demonstrated that fucoidan stimulates the antigen-presenting functions of dendritic cells. In this study we investigated the radioprotective effects of fucoidan on bone marrow cells BMCs which are the main cellular reservoir for the hematopoietic and immune system. To evaluate the effects of fucoidan we assayed cell viability and immune responses. In a viability assay fucoidan significantly increased the viability of BMCs. Based on the results of flow cytometric analysis the increased viability of fucoidan-treated BMCs was attributed to the inhibition of radiation-induced apoptosis. Furthermore fucoidan altered the production of immune-related cytokines from BMCs and increased the capability of BMCs to induce proliferation of allogeneic splenocytes. Taken together our study demonstrated that fucoidan has radioprotective effects on BMCs with respect to cell viability and immunoreactivity. These results may provide valuable information useful in the field of radiotherapy. Keywords bone marrow cells fucoidan immunoreactivity radioprotection Introduction Bone marrow contains a variety of cells that are required to maintain the hematopoietic and immune systems. On exposure to ionizing radiation bone marrow is profoundly damaged and severe .
