Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Optimization of 5-fluorouracil solid-lipid nanoparticles: a preliminary study to treat colon cancer. | Int. J. Med. Sci. 2010 7 398 Research Paper International Journal of Medical Sciences 2010 7 6 398-408 Ivyspring International Publisher. All rights reserved Optimization of 5-fluorouracil solid-lipid nanoparticles a preliminary study to treat colon cancer Alaa Eldeen B. Yassin1 2 Md. Khalid Anwer3 Hammam A. Mowafy1 Ibrahim M. El-Bagory1 Mohsen A. Bayomi1 2 and Ibrahim A. Alsarra1 2 H 1. Department of Pharmaceutics College of Pharmacy King Saud University . Box 2457 Riyadh 11451 Saudi Arabia 2. Center of Excellence in Biotechnology Research King Saud University . Box 2460 Riyadh 11451 Saudi Arabia 3. College of Pharmacy Al-Kharj University Al-Kharj Saudi Arabia H Corresponding author Professor Ibrahim A. Alsarra Phone 966 -1-4677504 Fax 966 -1-4676363 E-mail ialsar-ra@ Received Accepted Published Abstract Solid lipid nanoparticle SLNs formulae were utilized for the release of 5-fluorouracil 5-FU inside the colonic medium for local treatment of colon cancer. SLNs were prepared by double emulsion-solvent evaporation technique w o w using triglyceride esters Dynasan 1 14 or Dynasan 1 18 along with soyalecithin as the lipid parts. Different formulation parameters including type of Dynasan soyalicithin Dynasan ratio drug total lipid ratio and polyvinyl alcohol PVA concentration were studied with respect to particle size and drug entrapment efficiency. Results showed that formula 8 F8 with composition of 20 5-FU 27 Dynasan 1 14 and 53 soyalithicin and F14 20 5-FU 27 Dynasan 1 18 and 53 soyalithicin which were stabilized by PVA as well as F10 with similar composition as F8 but stabilized by 2 PVA were considered the optimum formulae as they combined small particle sizes and relatively high encapsulation efficiencies. F8 had a particle size of nm with a polydispersity value of and an encapsulation efficiency of 51 F10 had a nm particle size with polydispersity value and .
