Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: A case of IgG4-related tubulointerstitial nephritis concurrent with Henoch-Schönlein purpura nephritis | Tamai et al. Allergy Asthma Clinical Immunology 2011 7 5 http content 7 1 5 ALLERGY ASTHMA CLINICAL IMMUNOLOGY CASE REPORT Open Access A case of IgG4-related tubulointerstitial nephritis concurrent with Henoch-Schonlein purpura nephritis 1 12 3 3 3 Rukako Tamai Yoshiyuki Hasegawa Satoshi Hisano Katsuhisa Miyake Hitoshi Nakashima and Takao Saito Abstract We describe a 72-year-old man who had been suffered from Henoch-Schonlein purpura HSP several times presented with hematoproteinuria with granular cast and general lymphadenopathy. The immunological examination of the serum showed polyclonal hypergammagloburinemia with high value of IgG4. The renal biopsy revealed interstitial inflammatory cell infiltration including infiltration of lymphocytes and plasma cells and segmental glomerulonephritis. Direct immunofluorescence microscopy revealed apparent positive staining with anti-human IgA and anti-human IgG in glomeruli anti-human IgG4 antibody staining showed many positive plasma cells in the interstitium. The patient was diagnosed with HSP nephritis that was complicated by IgG4-related nephropathy. As a result of the treatment with 30mg prednisolone the swelling of the LNs decreased but the patient continued to have persistent hematoproteinuria. Introduction A novel clinicopathological entity of IgG4-related autoimmune disease characterized by extensive IgG4-positive plasma cell infiltration of organs together with CD4- or CD8-positive T lymphocytes is proposed 1 . Renal involvement in this entity was also suggested and three patterns of renal involvement have been described 1 extraparenchymal involvement such as hydronephrosis associated with retroperitoneal lesions 2 diffuse tubulointerstitial nephritis TIN and 3 renal lesions composed of focal lymphoplasmacytic infiltration of the renal interstitium 2 . In this report we describe a rare case diagnosed with HSP nephritis that was complicated by IgG4-related nephropathy. Case report A 72-year-old
