Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Phobic memory and somatic vulnerabilities in anorexia nervosa: a necessary unity? | Annals of General Psychiatry BioMed Central Review Open Access Phobic memory and somatic vulnerabilities in anorexia nervosa a necessary unity Michael Myslobodsky Address Howard University and Cerebral Brain Disorder Branch NIMH NIH Bethesda MD 20892-1379 USA Email Michael Myslobodsky - myslobom@ Corresponding author Published 06 September 2005 Received 26 March 2005 . I n . J_. I S I rnz n . fti-oxz A II- Accepted 06 September 2005 Annals of General Psychiatry 2005 4 15 doi 1744-859X-4-15 This article is available from http content 4 1 15 2005 Myslobodsky licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Anorexia nervosa is a clinically significant illness that may be associated with permanent medical complications involving almost every organ system. The paper raises a question whether some of them are associated with premorbid vulnerability such as subcellular ion channel abnormalities channelopathy that determines the clinical expression of the bodily response to self-imposed malnutrition. Aberrant channels emerge as a tempting if rather speculative alternative to the notion of cognitively-driven neurotransmitter modulation deficit in anorexia nervosa. The concept of channelopathies is in keeping with some characteristics of anorexia nervosa such as a genetically-based predisposition to hypophagia early onset cardiac abnormalities an appetiteenhancing efficacy of some antiepileptic drugs and others. The purpose of this article is to stimulate further basic research of ion channel biophysics in relation to restrictive anorexia. Introduction Anorexia nervosa AN is an intractable illness with a high long-term mortality that affects 1 to of the young
