Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Advanced paternal age is a risk factor for schizophrenia in Iranians. | Naserbakht et al. Annals of General Psychiatry 2011 10 15 http content 10 1 15 ANNALS OF GENERAL PSYCHIATRY PRIMARY RESEARCH Open Access Advanced paternal age is a risk factor for schizophrenia in Iranians Morteza Naserbakht1 2 Hamid-Reza Ahmadkhaniha2 3 4 Bahareh Mokri5 and Cassandra L Smith6 Abstract Background Since 1958 many but not all studies have demonstrated that paternal age is a risk factor for schizophrenia. There may be many different explanations for differences between studies including study design sample size collection criteria heterogeneity and the confounding effects of environmental factors that can for example perturb epigenetic programming and lead to an increase in disease risk. The small number of children in Western families makes risk comparisons between siblings born at different paternal ages difficult. In contrast more Eastern families have children both at early and later periods of life. In the present study a cross-sectional population study in an Iranian population was performed to compare frequency of schizophrenia in younger offspring that is older paternal age versus older offspring. Methods A total of 220 patients with the diagnosis of schizophrenia cases from both psychiatric hospitals and private clinics and 220 individuals from other hospital wards controls matched for sex and age were recruited for this study. Patients with neurological problem substance abuse mental retardation and mood disorder were excluded from both groups. Results Birth rank comparisons revealed that 35 vs 24 of the cases vs the controls were in the third or upper birth rank P . Also the mean age of fathers at birth in case group 30 years was significantly more than the control group years P . The age of 76 fathers at birth in case group was over 32 versus 33 fathers in control group. Individuals whose fathers age was more than 32 at birth were at higher risk times for schizophrenia .
