Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Autoantibodies to low-density-lipoprotein-receptor-related protein 2 (LRP2) in systemic autoimmune diseases. | Arthritis Research Therapy Vol 5 No 3 Ooka et al. Research article Open Access Autoantibodies to low-density-lipoprotein-receptor-related protein 2 LRP2 in systemic autoimmune diseases Seido Ooka1 Toshihiro Matsui1 2 Kusuki Nishioka1 and Tomohiro Kato1 1 Department of Bioregulation Institute of Medical Science St Marianna University School of Medicine Kawasaki Kanagawa Japan 2Clinical Research Center for Allergy and Rheumatology National Sagamihara Hospital Kanagawa Japan Corresponding author Tomohiro Kato e-mail t3kato@ Received 14 Nov 2002 Revisions requested 19 Dec 2002 Revisions received 4 Feb 2003 Accepted 6 Mar 2003 Published 4 Apr 2003 Arthritis Res Ther 2003 5 R174-R180 DOI ar754 2003 Ooka et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract We previously reported that autoantibodies autoAbs to the main epitope on CD69 reacted to its homologous amino acid sequence in low-density-lipoprotein-receptor-related protein 2 LPR2 a multiligand receptor for protein reabsorption. In this study we have investigated the prevalence autoepitope distribution and clinical significance of the autoAbs to LRP2 in patients with systemic autoimmune diseases. Using six recombinant proteins F2 F7 for LRP2 and one for CD69 we detected autoAbs to LRP2 in sera of patients with rheumatoid arthritis RA systemic lupus erythematosus Behpet s disease systemic sclerosis and osteoarthritis and then mapped autoepitopes by Western blotting. The autoAbs to LRP2 were detected in 87 of the patients with rheumatoid arthritis 40 of those with systemic lupus erythematosus 35 of those with systemic sclerosis 15 of those with osteoarthritis and 3 of those with Behget s disease. Multiple epitopes on LRP2 were recognized by most of the anti-LRP2 .
