Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Estrogen receptor-α gene haplotype is associated with primary knee osteoarthritis in Korean population. | Available online http content 6 5 R415 Research article Estrogen receptor-a gene haplotype is associated with primary knee osteoarthritis in Korean population Sheng-Yu Jin 1 Seung-Jae Hong 2 Hyung In Yang3 Sang-do Park3 Myung-Chul Yoo4 Hee Jae Lee1 Mee-Suk Hong1 Hae-Jeong Park1 Seo Hyun Yoon1 Bum-Shik Kim1 Sung-Vin Yim1 Hun-Kuk Park1 and Joo-Ho Chung1 Open Access 1Kohwang Medical Research Institute Department of Pharmacology College of Medicine Kyung Hee University Seoul Korea 2Department of Internal Medicine College of Medicine Pochon CHA University Sungnam Korea 3Division of Rheumatology Department of Internal Medicine College of Medicine Kyung Hee University Seoul Korea 4Department of Orthopedic Surgery College of Medicine Kyung Hee University Seoul Korea Contributed equally Corresponding author Joo-Ho Chung jhchung@ Received 19 Feb 2004 Revisions requested 5 Apr 2004 Revisions received 26 May 2004 Accepted 8 Jun 2004 Published 19 Jul 2004 Arthritis Res Ther 2004 6 R415-R421 DOI ar1207 2004 Jin et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Estrogen and estrogen receptors ERs are known to play important roles in the pathophysiology of osteoarthritis OA . To investigate ER-a gene polymorphisms for its associations with primary knee OA we conducted a case-control association study in patients with primary knee OA n 151 and healthy individuals n 397 in the Korean population. Haplotyping analysis was used to determine the relationship between three polymorphisms in the ER-a gene intron 1 T C intron 1 A G and exon 8 G A and primary knee OA. Genotypes of the ER-a gene polymorphism were determined by PCR followed by restriction enzyme digestion PvuII for intron 1 T C XbaI for intron 1 A G and BtgI for exon 8 G A polymorphism . There was
