Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Clinical implications of novel activating EGFR mutations in malignant peritoneal mesothelioma | Foster et al. World Journal of Surgical Oncology 2010 8 88 http content 8 1 88 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Clinical implications of novel activating EGFR mutations in malignant peritoneal mesothelioma 14 1 1 1 2 Jason M Foster Uppala Radhakrishna Venkatesh Govindarajan Joseph H Carreau Zoran Gatalica Poonam Sharma2 Swapan K Nath3 Brian W Loggie1 Abstract Background There is a paucity of information about the molecular perturbations involved in MPM tumor formation. We previously reported that EGFR-TK mutations in MPM were predictive of achieving optimal surgical cytoreduction but the status of EGFR pathway activation potential of these mutations was not known. Here we present the mutant EGFR activating potential and the matured survival data of the EGFR mutant mut relative to wild type EGFR mut- mesothelioma. Methods Twenty-nine patients were evaluated and their tumors were probed for mutations in the catalytic TK-domain. Twenty-five patients were treated with cytoreductive surgery and complete clinical data was available for comparison of the mut and mut- groups. A COS-7 cell expression model was used to determine mutation activating profiles and response to erlotinib. Results Functional mutations were found in 31 9 29 of patients 7 of these mutations were novel and another was the L858R mutation. All missense mutations were found to be activating mutations and responsive to erlotinib. Of the 25 patients managed surgically there were 7 mut and 18 mut-. Two of 7 29 mut developed progressive disease and died with a median follow-up time of 22 months while 13 18 72 mut- developed progressive disease and 10 18 56 died with median TTP of 12 months and median survival of 14 months. Conclusions The novel EGFR mutations identified are activating mutations responsive to erlotinib. The mut subset have a relative improved outcome. Erlotinib may have a role in MPM and exploration for mutations in a larger patient cohort is warranted. .
