Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Eag and HERG potassium channels as novel therapeutic targets in cancer | Asher et al. World Journal of Surgical Oncology 2010 8 113 http content 8 1 113 5 t WORLD JOURNAL OF SURGICAL ONCOLOGY REVIEW Open Access Eag and HERG potassium channels as novel therapeutic targets in cancer f V Ar l k r1l_I S I Z 1 I G r r2 Dz p. r CP s az3A i P O slì4D P I s IX A 5 Viren Asher Heidi sowter Robert Shaw Anish Bali Raheela Khan Abstract Voltage gated potassium channels have been extensively studied in relation to cancer. In this review we will focus on the role of two potassium channels Ether à-go-go Eag Human ether à-go-go related gene HERG in cancer and their potential therapeutic utility in the treatment of cancer. Eag and HERG are expressed in cancers of various organs and have been implicated in cell cycle progression and proliferation of cancer cells. Inhibition of these channels has been shown to reduce proliferation both in vitro and vivo studies identifying potassium channel modulators as putative inhibitors of tumour progression. Eag channels in view of their restricted expression in normal tissue may emerge as novel tumour biomarkers. Introduction Cancer is one of the major killers throughout the world. It is estimated that a total of 1 529 560 new cancer cases and 569 490 deaths from cancer will occur in the United States in 2010 1 . There is increasing evidence that ion channels are involved in various processes characteristic of cancer cells such as uncontrolled cell proliferation migration and survival in hypoxic conditions 2 . Ion channels are integral membrane proteins that mediate the transfer of ions through the hydrophobic lipid bilayer of the cell membrane. They play an important role in a variety of functions that range from nerve muscle excitation 3 regulation of blood pressure 4 through to sperm motility and capacitation 5 . Potassium K channels comprise the largest family of ion channels encoded by 300 genes with phenotypic diversity generated through alternative splicing variable association of homo .
