Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Levels of gastrin-releasing peptide and substance P in synovial fluid and serum correlate with levels of cytokines in rheumatoid arthritis. | Available online http content 7 3 R416 Research article Levels of gastrin-releasing peptide and substance P in synovial fluid and serum correlate with levels of cytokines in rheumatoid arthritis Ola Grimsholm1 Solbritt Rantapaa-Dahlqvist2 and Sture Forsgren1 Department of Integrative Medical Biology Section for Anatomy Umea University Umea Sweden 2Department of Rheumatology Umea University Hospital Umea Sweden Corresponding author Ola Grimsholm Received 27 Sep 2004 Revisions requested 7 Dec 2004 Revisions received 21 Dec 2004 Accepted 4 Jan 2005 Published 7 Feb 2005 Arthritis Research Therapy 2005 7 R416-R426 DOI 86 ar1503 2005 Grimsholm et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Open Access Abstract It is well known that cytokines are highly involved in the disease process of rheumatoid arthritis RA . Recently targeting of neuropeptides has been suggested to have potential therapeutic effects in RA. The aim of this study was to investigate possible interrelations between five neuropeptides bombesin gastrin-releasing peptide BN GRP substance P SP vasoactive intestinal peptide calcitonin-gene-related peptide and neuropeptide Y and the three cytokines tumour necrosis factor TNF -a IL-6 and monocyte chemoattractant protein-1 in synovial fluid of patients with RA. We also investigated possible interrelations between these neuropeptides and soluble TNF receptor 1 in serum from RA patients. Synovial fluid and sera were collected and assayed with ELISA or RIA. The most interesting findings were correlations between BN GRP and SP and the cytokines. Thus in synovial fluid the concentrations of BN GRP and SP grouped together with IL-6 and SP also grouped together with TNF-a
