Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblasts. | Available online http content 7 3 R476 Research article Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblasts Shingo Nakayamada1 Hitoshi Kurose2 Kazuyoshi Saito1 Akira Mogami3 and Yoshiya Tanaka1 1First Department of Internal Medicine University of Occupational and Environmental Health School of Medicine Fukuoka Japan 2Department of Pharmacology and Toxicology Graduate School of Pharmaceutical Sciences Kyushu University Fukuoka Japan 3Pharmaceuticals Research Unit Research Development Division Mitsubishi Pharma Corporation Yokohama Japan Corresponding author Yoshiya Tanaka tanaka@ Received 11 Nov 2004 Revisions requested 24 Nov 2004 Revisions received 10 Jan 2005 Accepted 18 Jan 2005 Published 18 Feb 2005 Arthritis Research Therapy 2005 7 R476-R484 DOI 86 ar1694 2005 Nakayamada et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Rho is a major small GTP-binding protein that is involved in the regulation of various cell functions including proliferation and cell migration through activation of multiple signaling molecules in various types of cells. We studied its roles in synovial fibroblasts SFs in patients with rheumatoid arthritis RA and clarified its relevance to RA synovitis with the following results. 1 We found that the thrombin receptor was overexpressed on RA synovial fibroblasts RA SFs and that thrombin induced a marked proliferation and progression of the cell cycle to the S phase in these cells. 2 We also found that thrombin efficiently activated Rho. 3 Rho activation and proliferation and the progression of the cell cycle to the S phase were completely blocked by p115RGS an N-terminal .
