Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Induction of a B-cell-dependent chronic arthritis with glucose-6-phosphate isomerase. | Available online http content 7 6 R1316 Research article Induction of a B-cell-dependent chronic arthritis with glucose-6-phosphate isomerase Robert Bockermann1 David Schubert2 Thomas Kamradt3 and Rikard Holmdahl4 Open Access Section for Medical Inflammation Research University of Lund Lund Sweden 2Deutsches Rheumaforschungszentrum Berlin Berlin Germany 3Deutsches Rheumaforschungszentrum Berlin and Institut fur Immunologie Klinikum der FSU Jena Germany 4Section for Medical Inflammation Research University of Lund Lund Sweden Corresponding author Rikard Holmdahl Received 8 Jun 2005 Revisions requested 18 Jul 2005 Revisions received 16 Aug 2005 Accepted 26 Aug 2005 Published 20 Sep 2005 Arthritis Research Therapy 2005 7 R1316-R1324 DOI ar1829 This article is online at http content 7 6 R1316 2005 Bockermann et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Antibodies specific for glucose-6-phosphate isomerase G6PI from T-cell receptor transgenic K BxN mice are known to induce arthritis in mice and immunization of DBA 1 mice with G6PI led to acute arthritis without permanent deformation of their joints. Because rheumatoid arthritis is a chronic disease we set out to identify the capacity of G6PI to induce chronic arthritis in mice. Immunization with recombinant human G6PI induced a chronically active arthritis in mice with a C3H genomic background whereas the DBA 1 background allowed only acute arthritis and the C57BL 10 background permitted no or very mild arthritis. The disease was associated with the major histocompatibility region sharing an allelic association similar to that of collagen-induced arthritis . q p r . All strains
