Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The interferon induced with helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis. | Available online http content 9 2 R40 Research article The interferon induced with helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis Ioanna Marinou1 Douglas S Montgomery2 Marion C Dickson2 Michael H Binks2 David J Moore1 Deborah E Bax1 and Anthony G Wilson1 Section of Musculoskeletal Sciences School of Medicine Biomedical Sciences The University of Sheffield Royal Hallamshire Hospital Sheffield S10 2RX UK 2GlaxoSmithKline R D Stevenage SG1 2NY UK Corresponding author Anthony G Wilson Received 22 Jan 2007 Revisions requested 27 Feb 2007 Revisions received 16 Apr 2007 Accepted 18 Apr 2007 Published 18 Apr 2007 Arthritis Research Therapy 2007 9 R40 doi ar2179 This article is online at http content 9 2 R40 2007 Marinou et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract An important feature of autoimmune diseases is the overlap of pathophysiological characteristics. Clustering of autoimmune diseases in families suggests that genetic variants may contribute to autoimmunity. The aim of the present study was to investigate the role of the interferon induced with helicase domain 1 IFIH1 A946T rs1990760 A G variant in rheumatoid arthritis RA as this was recently associated with susceptibility to type 1 diabetes. A total of 965 Caucasians with RA and 988 healthy controls were genotyped for IFIH1 A946T. Gene expression of IFIH1 was measured in peripheral blood leukocytes using real-time PCR. Genotypes were equally distributed in both RA cases and healthy controls odds ratio for allele C 95 confidence interval P . No association was detected after stratification by sex age at onset .
