Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Vasoactive intestinal peptide inhibits TNF-α-induced apoptotic events in acinar cells from nonobese diabetic mice submandibular glands. | Available online http content 11 2 R53 Research article Vasoactive intestinal peptide inhibits TNF-a-induced apoptotic events in acinar cells from nonobese diabetic mice submandibular glands Mario Calafat1 2 Luciana Larocca1 2 Valeria Roca1 2 Vanesa Hauk1 2 Nicolás Pregi1 2 Alcira Nesse1 2 and Claudia Pérez Leirós1 2 Open Access 1Departamento de Química Biológica Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires Ciudad Universitaria Pabellón II 4 piso 1428 Buenos Aires Argentina 2Consejo Nacional de Investigaciones Cientificas y Técnicas Avda. Rivadavia 1917 CP C1033AAJ Buenos Aires Argentina Corresponding author Claudia Pérez Leirós cpleiros@ Received 9 Feb 2009 Revisions requested 24 Mar 2009 Revisions received 1 Apr 2009 Accepted 8 Apr 2009 Published 8 Apr 2009 Arthritis Research Therapy 2009 11 R53 doi ar2671 This article is online at http content 11 2 R53 2009 Calafat et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction The role of apoptotic secretory epithelium as a pro-inflammatory triggering factor of exocrine dysfunction is currently explored in Sjogren s syndrome patients and in the nonobese diabetic NOD mouse model. Vasoactive intestinal peptide VIP has anti-inflammatory effects in various models of chronic inflammation. Our goal was to analyse the effect of TNF-a on apoptotic mediators in isolated acinar cells from NOD submandibular gland and their modulation by VIP. Methods Acinar cells were isolated from submandibular glands of 16-week-old NOD females with salivary flow decline. Age-matched BALB c females or eight-week-old NOD females were used as controls. Apoptotic mediators and TNF-a receptor .
