Báo cáo y học: "Identification of novel genetic susceptibility loci for Behçet's disease using a genome-wide association study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Identification of novel genetic susceptibility loci for Behçet's disease using a genome-wide association study. | Available online http content 11 3 R66 Research article Identification of novel genetic susceptibility loci for Behẹet s disease using a genome-wide association study Yiping Fei1 2 Ryan Webb2 3 Beth L Cobb2 4 Haner Direskeneli5 Guher Saruhan-Direskeneli6 and Amr H Sawalha1 2 7 1 Department of Medicine University of Oklahoma Health Sciences Center 825 NE 13th Street Oklahoma City OK 73104 USA 2Arthritis Immunology Program Oklahoma Medical Research Foundation 825 NE 13th Street Oklahoma City OK 73104 USA 3College of Public Health University of Oklahoma Health Sciences Center 825 NE 13th Street Oklahoma City OK 73104 USA 4JK Autoimmunity Inc. 755 Research Parkway Oklahoma City OK 73104 USA 5Division of Rheumatology Department of Internal Medicine Marmara University Medical School Tophanelioglu Cad. 13 15 34662 Uskudar Istanbul Turkey department of Physiology Istanbul Faculty of Medicine Istanbul University Capa 34093 Istanbul Turkey 7US Department of Veterans Affairs Medical Center 921 NE 13th Street Oklahoma City OK 73104 USA Corresponding author Amr H Sawalha amr-sawalha@ Received 31 Mar 2009 Revisions requested 28 Apr 2009 Revisions received 3 May 2009 Accepted 14 May 2009 Published 14 May 2009 Arthritis Research Therapy 2009 11 R66 doi ar2695 This article is online at http content 11 3 R66 2009 Fei et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Behget s disease is a chronic systemic inflammatory disease that remains incompletely understood. Herein we perform the first genome-wide association study in Behget s disease. Methods Using DNA pooling technology and the Affymetrix 500K arrays we identified possible candidate .

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