Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: SAPHO syndrome: Is a range of pathogen-associated rheumatic diseases extended? | Available online http content 11 6 131 Editorial SAPHO syndrome Is a range of pathogen-associated rheumatic diseases extended Alexander P Rozin B. Shine Department of Rheumatology Rambam Health Care Campus and Rappaport Faculty of Medicine Technion . Box 9602 Haifa Bat-Galim 31096 Israel Corresponding author Alexander P Rozin a_rozin@ Published 5 November 2009 Arthritis Research Therapy 2009 11 131 doi ar2837 This article is online at http content 11 6 131 2009 BioMed Central Ltd See related research by Assmann et al. http content 11 5 R140 Abstract SAPHO syndrome representing a constellation of synovitis acne palmo-plantar pustulosis hyperostosis and osteitis is now recognized as a distinct medical entity a reactive infectious osteitis. Genetic immunological and bacterial mechanisms are implicated in the development of the disease. Diagnostic problems may arise due to non-complete manifestations of SAPHO either acne and arthritis or acne and anterior wall osteitis with an unclear pustulosis history. The interventional study of Assmann et al. is a significant addition to a long range of publications showing an association of SAPHO with Propionibacterium acnes. Randomized control studies are needed to confirm the effects of antibiotic therapy. In the previous issue of Arthritis Research Therapy an interventional study of patients with SAPHO synovitis acne pustulosis hyperostosis osteitis syndrome a skin-osteo-articular inflammatory disease showed positive bacteriological cultures for Propionibacterium acnes in 14 of 21 67 patients who had undergone a needle biopsy of osteitis lesions 1 . This is a significant addition to a long range of publications showing an association of SAPHO with P. acnes in 42 of patients Table 1 . The activity of SAPHO by assessment of skin disease health assessment score radiological activity score and osteitis lesions by magnetic resonance .
